Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.51 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | G6PD | P11413 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9888489 | 0.89 | AKR1C3 (0.60) | SMN1; SMN2MEN1KMT2AL3MBTL1AKR1C3 | |
| SCHEMBL1707828 | 0.86 | SMN1; SMN2 (0.53) | SMN1; SMN2MEN1KMT2APOLBAKR1C3 | |
| SCHEMBL10008943 | 0.83 | MAPK1 (0.55) | SMN1; SMN2MEN1KMT2APOLBL3MBTL1 | |
| SCHEMBL10010086 | 0.82 | AKR1C3 (0.55) | SMN1; SMN2MEN1KMT2APOLBAKR1C3 | |
| SCHEMBL17772043 | 0.82 | AKR1C3 (0.55) | SMN1; SMN2MEN1KMT2AL3MBTL1AKR1C3 | |
| SCHEMBL1707762 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2MEN1KMT2APOLBAKR1C3 | |
| SCHEMBL28567894 | 0.79 | KCNMA1 (0.58) | SMN1; SMN2MEN1KMT2AL3MBTL1AKR1C3 | |
| SCHEMBL2112961 | 0.78 | AKR1C3 (0.67) | SMN1; SMN2MEN1KMT2AL3MBTL1AKR1C3 | |
| SCHEMBL29532900 | 0.78 | AKR1C3 (0.67) | SMN1; SMN2MEN1KMT2AL3MBTL1AKR1C3 | |
| SCHEMBL4847691 | 0.77 | AKR1C3 (0.60) | SMN1; SMN2MEN1KMT2AAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120172351-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-07-05 | — | — | US | disclosed |
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172351-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | GPR119, INSR, GLP1R | SMN1; SMN2 4287/4885MEN1 1867/4885KMT2A 4170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.