Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1936439 | 0.87 | HTT (0.44) | HTTALDH1A1MAPTTDP1NPSR1 | |
| SCHEMBL1786298 | 0.83 | HTT (0.71) | HTTALDH1A1MAPTTDP1NPSR1 | |
| SCHEMBL3956902 | 0.81 | HTT (0.69) | HTTALDH1A1MAPTTDP1NPSR1 | |
| SCHEMBL17087766 | 0.79 | MPI (0.41) | HTTALDH1A1NPSR1LMNAPOLB | |
| SCHEMBL23390695 | 0.78 | HTT (0.67) | HTTALDH1A1MAPTTDP1NPSR1 | |
| SCHEMBL6328466 | 0.77 | HTT (0.50) | HTTALDH1A1MAPTTDP1NPSR1 | |
| SCHEMBL529463 | 0.76 | NLRP3 (0.46) | HTTALDH1A1MAPTTDP1POLB | |
| SCHEMBL1219245 | 0.76 | CTSK (0.39) | HTTALDH1A1LMNATSHRTP53 | |
| SCHEMBL23390647 | 0.75 | HTT (1.00) | HTTALDH1A1MAPTTDP1NPSR1 | |
| SCHEMBL4223857 | 0.75 | HTT (0.64) | HTTALDH1A1MAPTTDP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116501-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY | Proteostasis Therapeutics, Inc. (US) | 2017-01-18 | — | — | EP | disclosed |
| WO-2015138909-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2015-09-17 | — | — | WO | disclosed |