Sugi Predict

Sugi Predict / Compounds / SCHEMBL6328466

SCHEMBL6328466

SCHEMBL6328466

CCOC(=O)c1noc(CCNC(=O)OC(C)(C)C)n1

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ HTT P42858 3/20 0.50
▸ ALDH1A1 P00352 6/20 0.47
▸ NPSR1 Q6W5P4 1/20 0.47
▸ MAPT P10636 1/20 0.44
▸ TDP1 Q9NUW8 1/20 0.44
▸ POLB P06746 1/20 0.41
▸ LMNA P02545 4/20 0.41
▸ HPGD P15428 2/20 0.41
▸ GAA P10253 1/20 0.41
▸ TSHR P16473 4/20 0.40
▸ MEN1 O00255 3/20 0.40
▸ KMT2A Q03164 3/20 0.40
▸ SMN1; SMN2 Q16637 2/20 0.40
▸ PKM P14618 1/20 0.40
▸ KDM4E B2RXH2 2/20 0.39
▸ GFER P55789 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5987499 0.88 HTT (0.38) HTTALDH1A1NPSR1MAPTLMNA
SCHEMBL18765021 0.85 HTT (0.54) HTTALDH1A1NPSR1MAPTTDP1
SCHEMBL24387685 0.82 HTT (0.53) HTTALDH1A1NPSR1MAPTTDP1
SCHEMBL3951349 0.80 HTT (0.51) HTTALDH1A1NPSR1MAPTTDP1
SCHEMBL23353904 0.79 MAPT (0.38) ALDH1A1MAPTPOLBLMNATSHR
SCHEMBL1785524 0.79 HTT (0.50) HTTALDH1A1NPSR1MAPTTDP1
SCHEMBL21906144 0.77 ALDH1A1 (0.38) ALDH1A1MEN1KMT2A
SCHEMBL29097160 0.77 HTT (0.51) HTTALDH1A1NPSR1MAPTTDP1
SCHEMBL14310928 0.77 HTT (0.46) HTTALDH1A1NPSR1MAPTTDP1
SCHEMBL17079404 0.77 HTT (0.60) HTTALDH1A1NPSR1MAPTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3364967-B1 FERROPORTIN INHIBITORS VIFOR INT AG (CH) 2026-05-20 — — EP disclosed
EP-3365339-B1 NOVEL FERROPORTIN INHIBITORS VIFOR INT AG (CH) 2025-07-16 — — EP disclosed
US-20220363675-A1 Novel Ferroportin Inhibitors VIFOR (INTERNATIONAL) AG (CH) 2022-11-17 — — US disclosed
CN-114668761-A Novel ferroportin inhibitors 威佛（国际）股份公司 2022-06-28 — — CN disclosed
CN-108290878-B Novel ferroportin inhibitors 威佛（国际）股份公司 2022-04-26 — — CN disclosed
US-11066399-B2 Ferroportin inhibitors VIFOR (INTERNATIONAL) AG (CH) 2021-07-20 — — US disclosed
US-20210139472-A1 Novel Ferroportin Inhibitors VIFOR (INTERNATIONAL) AG (CH) 2021-05-13 — — US disclosed
US-11001579-B2 Ferroportin inhibitors VIFOR (INTERNATIONAL) AG (CH) 2021-05-11 — — US disclosed
US-11001579-B2 Ferroportin inhibitors VIFOR (INTERNATIONAL) AG (CH) 2021-05-11 — — US disclosed
US-10738041-B2 Ferroportin inhibitors VIFOR (INTERNATIONAL) AG (CH) 2020-08-11 — — US disclosed
US-20180297991-A1 Novel Ferroportin Inhibitors VIFOR (INTERNATIONAL) AG (CH) 2018-10-18 — — US disclosed
EP-3364967-A2 FERROPORTIN INHIBITORS Vifor (International) AG (CH) 2018-08-29 — — EP disclosed
EP-3365339-A1 NOVEL FERROPORTIN INHIBITORS Vifor (International) AG (CH) 2018-08-29 — — EP disclosed
WO-2017068090-A1 NOVEL FERROPORTIN INHIBITORS VIFOR (INTERNATIONAL) AG (CH) 2017-04-27 — — WO disclosed
WO-2017068089-A2 NOVEL FERROPORTIN INHIBITORS VIFOR (INTERNATIONAL) AG (CH) 2017-04-27 — — WO disclosed
WO-2017068089-A2 NOVEL FERROPORTIN INHIBITORS VIFOR (INTERNATIONAL) AG (CH) 2017-04-27 — — WO disclosed
WO-2017068090-A1 NOVEL FERROPORTIN INHIBITORS VIFOR (INTERNATIONAL) AG (CH) 2017-04-27 — — WO disclosed
US-6951946-B2 Large scale synthesis of 1,2,4- and 1,3,4-oxadiazole carboxylates LEXICON PHARMACEUTICALS, INC. (US) 2005-10-04 — — US disclosed
US-20050154211-A1 Large scale synthesis of 1,2,4- and 1,3,4- oxadiazole carboxylates KOLB HARTMUTH C (US) 2005-07-14 — — US disclosed
US-20040019215-A1 Large scale synthesis of 1,2,4- and 1,3,4-oxadiazole carboxylates LEXICON PHARMACEUTICALS, INC. 2004-01-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210139472-A1 Novel Ferroportin Inhibitors HAMP, SLC40A1, HMOX1 HTT 487/4885ALDH1A1 2812/4885NPSR1 3429/4885
US-10738041-B2 Ferroportin inhibitors SLC40A1, HAMP, TFRC HTT 1074/4885ALDH1A1 1968/4885NPSR1 3328/4885
US-11066399-B2 Ferroportin inhibitors HAMP, SLC40A1, FTH1 HTT 527/4885ALDH1A1 2395/4885NPSR1 3513/4885
US-20180297991-A1 Novel Ferroportin Inhibitors SLC40A1, HAMP, TFRC HTT 1291/4885ALDH1A1 1922/4885NPSR1 3550/4885
US-20050154211-A1 Large scale synthesis of 1,2,4- and 1,3,4- oxadiazole carboxylates OXA1L, ODC1, CYP4B1 HTT 3346/4885ALDH1A1 85/4885NPSR1 3994/4885
US-11001579-B2 Ferroportin inhibitors HAMP, SLC40A1, FTH1 HTT 527/4885ALDH1A1 2395/4885NPSR1 3513/4885
US-20040019215-A1 Large scale synthesis of 1,2,4- and 1,3,4-oxadiazole carboxylates OXA1L, ODC1, CYP4B1 HTT 3346/4885ALDH1A1 85/4885NPSR1 3994/4885
US-20220363675-A1 Novel Ferroportin Inhibitors HAMP, SLC40A1, HMOX1 HTT 487/4885ALDH1A1 2812/4885NPSR1 3429/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.