Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | CTSE | P14091 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2875383 | 0.89 | HRH3 (0.44) | GPR119HRH3DDB1CRBNKDM4E | |
| SCHEMBL1707965 | 0.86 | GPR119 (0.44) | GPR119DDB1CRBNMEN1KMT2A | |
| SCHEMBL1707960 | 0.84 | GPR119 (0.34) | GPR119HRH3DDB1CRBNCNR2 | |
| SCHEMBL27154630 | 0.81 | CTSD (0.43) | GPR119HRH3DDB1CRBNMEN1 | |
| Hydrochloric Acid SCHEMBL485037 | 0.81 | GPR119 (0.40) | GPR119HRH3CNR2 | |
| SCHEMBL314119 | 0.80 | USP2 (0.47) | GPR119DDB1CRBNKDM4EMAPT | |
| SCHEMBL484635 | 0.80 | HRH3 (0.36) | HRH3 | |
| SCHEMBL27146369 | 0.78 | DDB1 (0.44) | GPR119HRH3DDB1CRBNKDM4E | |
| SCHEMBL993941 | 0.77 | HPGD (0.49) | GPR119KDM4EMAPTTHRBCTSD | |
| SCHEMBL1707967 | 0.77 | GPR119 (0.45) | GPR119DDB1CRBNKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440542-A1 | SUBSTITUTED BENZIMIDAZOLES, BENZOTHIAZOLES AND BENZOXAZOLES | Grünenthal GmbH (DE) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010142402-A1 | SUBSTITUTED BENZIMIDAZOLES, BENZOTHIAZOLES AND BENZOXAZOLES | Grünenthal GmbH (DE) | 2010-12-16 | — | — | WO | disclosed |