Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL314119 | 0.88 | USP2 (0.47) | GPR119DDB1CRBNKDM4EMAPT | |
| SCHEMBL1707965 | 0.83 | GPR119 (0.44) | GPR119DDB1CRBNKDM4EMAPT | |
| SCHEMBL20068603 | 0.83 | GPR119 (0.47) | GPR119KDM1AKDM4EMAPTTHRB | |
| SCHEMBL6626522 | 0.81 | MAPT (0.48) | GPR119DDB1CRBNKDM1AKDM4E | |
| SCHEMBL20077137 | 0.80 | GPR119 (0.48) | GPR119KDM4EMAPTTHRBHPGD | |
| SCHEMBL14297530 | 0.80 | USP2 (0.45) | GPR119DDB1CRBNKDM4EMAPT | |
| SCHEMBL16835469 | 0.80 | CYP11B2 (0.51) | DDB1CRBNUSP2SMN1; SMN2 | |
| SCHEMBL2875383 | 0.79 | HRH3 (0.44) | GPR119DDB1CRBNKDM4EMAPT | |
| SCHEMBL20461156 | 0.78 | GPR119 (0.47) | GPR119KDM1AKDM4EMAPTTHRB | |
| SCHEMBL1707959 | 0.77 | GPR119 (0.39) | GPR119DDB1CRBNKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440542-A1 | SUBSTITUTED BENZIMIDAZOLES, BENZOTHIAZOLES AND BENZOXAZOLES | Grünenthal GmbH (DE) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010142402-A1 | SUBSTITUTED BENZIMIDAZOLES, BENZOTHIAZOLES AND BENZOXAZOLES | Grünenthal GmbH (DE) | 2010-12-16 | — | — | WO | disclosed |