Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.45 |
| ▸ | HTR2C | P28335 | 6/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17080056 | 0.87 | HTR2C (0.46) | ROCK2HTR2CTSHR | |
| SCHEMBL17080007 | 0.83 | ROCK2 (0.49) | ROCK2HTR2CFPR2TSHR | |
| SCHEMBL18083927 | 0.83 | ROCK2 (0.64) | ROCK2HTR2CFPR2TSHRSIRT2 | |
| SCHEMBL17080091 | 0.80 | FPR2 (0.50) | ROCK2HTR2CFPR2TSHRHDAC6 | |
| SCHEMBL17079989 | 0.79 | ROCK2 (0.59) | ROCK2FPR2HDAC6 | |
| SCHEMBL17080069 | 0.78 | ROCK2 (0.46) | ROCK2HTR2CFPR2TSHR | |
| SCHEMBL17080024 | 0.77 | ROCK2 (0.47) | ROCK2HTR2CHDAC6 | |
| SCHEMBL17079979 | 0.75 | ROCK2 (0.51) | ROCK2FPR2TSHR | |
| SCHEMBL17079983 | 0.75 | ROCK2 (0.61) | ROCK2HTR2C | |
| SCHEMBL17080060 | 0.74 | TSHR (0.39) | TSHRSIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116877-A1 | CHEMICAL COMPOUNDS ACTING AS PERK INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2017-01-18 | — | — | EP | disclosed |
| WO-2015136463-A1 | CHEMICAL COMPOUNDS ACTING AS PERK INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2015-09-17 | — | — | WO | disclosed |
| WO-2015136463-A1 | CHEMICAL COMPOUNDS ACTING AS PERK INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2015-09-17 | — | — | WO | disclosed |