Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.39 |
| ▸ | VNN1 | O95497 | 2/20 | 0.34 |
| ▸ | ME2 | P23368 | 1/20 | 0.33 |
| ▸ | ME1 | P48163 | 1/20 | 0.33 |
| ▸ | ME3 | Q16798 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.30 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.30 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2562645 | 0.84 | HDAC6 (0.41) | HDAC6HDAC3HDAC1HDAC2VNN1 | |
| SCHEMBL19942194 | 0.75 | VNN1 (0.39) | HDAC6HDAC3HDAC1HDAC2VNN1 | |
| SCHEMBL2566143 | 0.74 | VNN1 (0.49) | HDAC6HDAC3HDAC1HDAC2VNN1 | |
| SCHEMBL2565965 | 0.74 | HDAC3 (0.31) | HDAC6HDAC3HDAC1HDAC2ME2 | |
| SCHEMBL12294290 | 0.73 | ATM (0.43) | — | |
| SCHEMBL2560278 | 0.72 | HDAC3 (0.53) | HDAC6HDAC3HDAC1HDAC2VNN1 | |
| SCHEMBL2560721 | 0.72 | VNN1 (0.47) | HDAC6HDAC3HDAC1HDAC2VNN1 | |
| SCHEMBL15009106 | 0.71 | CLK1 (0.43) | VNN1MAPK8MAPK9MAPK10 | |
| SCHEMBL2561455 | 0.70 | KCNA5 (0.36) | KCNA5CACNA1G | |
| SCHEMBL2560412 | 0.70 | GPR55 (0.45) | HDAC6HDAC3HDAC1HDAC2VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133123-B2 | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use | CYTOKINETICS, INC. (US) | 2015-09-15 | — | — | US | disclosed |