Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR55 | Q9Y2T6 | 6/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29724999 | 0.84 | CYP11B2 (0.41) | GPR55CYP11B1CYP11B2HDAC6VNN1 | |
| SCHEMBL12288603 | 0.84 | CYP11B2 (0.41) | GPR55CYP11B1CYP11B2HDAC6VNN1 | |
| SCHEMBL12288595 | 0.82 | ULK1 (0.41) | GPR55CYP11B1CYP11B2HDAC6SCN10A | |
| SCHEMBL29724758 | 0.82 | ULK1 (0.41) | GPR55CYP11B1CYP11B2HDAC6SCN10A | |
| SCHEMBL22365490 | 0.81 | ULK1 (0.44) | CYP11B2HDAC6SCN10AVNN1HDAC3 | |
| SCHEMBL2562645 | 0.76 | HDAC6 (0.41) | HDAC6VNN1HDAC3HDAC1HDAC2 | |
| SCHEMBL2563470 | 0.74 | VNN1 (0.39) | CYP11B1CYP11B2HDAC6VNN1 | |
| SCHEMBL12288597 | 0.74 | VNN1 (0.44) | HDAC6VNN1HDAC3HDAC1HDAC2 | |
| SCHEMBL14937159 | 0.74 | MAPT (0.40) | VNN1 | |
| SCHEMBL2562385 | 0.73 | CLK1 (0.45) | VNN1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560653-A1 | CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | Cytokinetics, Inc. (US) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011133888-A1 | CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS, INC. (US) | 2011-10-27 | — | — | WO | disclosed |