Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708399 | 0.92 | TSHR (0.38) | LMNASMN1; SMN2NPC1ALDH1A1HPGD | |
| SCHEMBL1708112 | 0.92 | TSHR (0.38) | LMNASMN1; SMN2NPC1ALDH1A1HPGD | |
| SCHEMBL1707944 | 0.92 | TSHR (0.38) | LMNASMN1; SMN2NPC1ALDH1A1HPGD | |
| SCHEMBL1708287 | 0.88 | MAPT (0.32) | LMNASMN1; SMN2NPC1ALDH1A1MAPK1 | |
| SCHEMBL1708628 | 0.88 | MAPT (0.32) | LMNASMN1; SMN2NPC1ALDH1A1MAPK1 | |
| SCHEMBL1708395 | 0.88 | MAPT (0.32) | LMNASMN1; SMN2NPC1ALDH1A1MAPK1 | |
| SCHEMBL1708091 | 0.87 | ADORA2B (0.31) | LMNASMN1; SMN2ALDH1A1MAPK1MAPT | |
| SCHEMBL1708165 | 0.85 | FFAR1 (0.42) | — | |
| SCHEMBL1708168 | 0.84 | NTRK1 (0.36) | LMNASMN1; SMN2ALDH1A1HPGDMAPK1 | |
| SCHEMBL1707942 | 0.84 | NTRK1 (0.36) | LMNASMN1; SMN2ALDH1A1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |