Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.31 |
| ▸ | MTOR | P42345 | 3/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708399 | 1.00 | TSHR (0.38) | TSHRMAPK1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1708112 | 1.00 | TSHR (0.38) | TSHRMAPK1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1708166 | 0.92 | LMNA (0.36) | TSHRMAPK1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1707942 | 0.92 | NTRK1 (0.36) | TSHRMAPK1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1708168 | 0.92 | NTRK1 (0.36) | TSHRMAPK1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1708395 | 0.91 | MAPT (0.32) | TSHRMAPK1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1708287 | 0.91 | MAPT (0.32) | TSHRMAPK1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1708425 | 0.91 | NTRK1 (0.36) | TSHRMAPK1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1708628 | 0.91 | MAPT (0.32) | TSHRMAPK1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1708091 | 0.90 | ADORA2B (0.31) | TSHRMAPK1SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |