Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570095 | 1.00 | ALDH1A1 (0.43) | ALDH1A1TAAR1S1PR1PDE7ARAB9A | |
| SCHEMBL4570136 | 0.94 | TAAR1 (0.39) | ALDH1A1TAAR1S1PR1RAB9AMAPT | |
| SCHEMBL17082166 | 0.94 | TAAR1 (0.39) | ALDH1A1TAAR1S1PR1RAB9AMAPT | |
| SCHEMBL4570094 | 0.92 | S1PR1 (0.43) | ALDH1A1TAAR1S1PR1MAPTHSD11B1 | |
| SCHEMBL17082083 | 0.92 | S1PR1 (0.43) | ALDH1A1TAAR1S1PR1MAPTHSD11B1 | |
| SCHEMBL17082129 | 0.90 | HSD11B1 (0.37) | TAAR1S1PR1HSD11B1CYP2C9 | |
| SCHEMBL4570096 | 0.90 | HSD11B1 (0.37) | TAAR1S1PR1HSD11B1CYP2C9 | |
| SCHEMBL3701831 | 0.89 | S1PR1 (0.39) | S1PR1HSD11B1CYP2C9 | |
| SCHEMBL2700830 | 0.89 | S1PR1 (0.39) | S1PR1HSD11B1CYP2C9 | |
| SCHEMBL2699415 | 0.88 | KDM4E (0.43) | ALDH1A1S1PR1MAPTHSD11B1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |