Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | AGPAT2 | O15120 | 4/20 | 0.34 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570096 | 1.00 | HSD11B1 (0.37) | HSD11B1S1PR1AGPAT2SERPINE1CYP2C9 | |
| SCHEMBL4570097 | 0.95 | ALK (0.35) | S1PR1AGPAT2SERPINE1CYP2C9TAAR1 | |
| SCHEMBL4570095 | 0.90 | ALDH1A1 (0.43) | HSD11B1S1PR1CYP2C9TAAR1 | |
| SCHEMBL17081995 | 0.90 | ALDH1A1 (0.43) | HSD11B1S1PR1CYP2C9TAAR1 | |
| SCHEMBL17082083 | 0.88 | S1PR1 (0.43) | HSD11B1S1PR1CYP2C9TAAR1 | |
| SCHEMBL4570094 | 0.88 | S1PR1 (0.43) | HSD11B1S1PR1CYP2C9TAAR1 | |
| SCHEMBL2700830 | 0.85 | S1PR1 (0.39) | HSD11B1S1PR1CYP2C9 | |
| SCHEMBL3701831 | 0.85 | S1PR1 (0.39) | HSD11B1S1PR1CYP2C9 | |
| SCHEMBL4570037 | 0.85 | KMT2A (0.35) | HSD11B1CYP2C9 | |
| SCHEMBL2699415 | 0.84 | KDM4E (0.43) | HSD11B1S1PR1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |