Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | PRKACA | P17612 | 2/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL978793 | 0.80 | ALDH1A1 (0.61) | HDAC3HDAC1HDAC10HDAC6PRKACA | |
| SCHEMBL7168778 | 0.79 | LMNA (0.53) | PRKACARPS6KB1GSK3BROCK1ALDH1A1 | |
| SCHEMBL13035832 | 0.79 | TNF (0.57) | PRKACARPS6KB1GSK3BROCK1ALDH1A1 | |
| SCHEMBL7168780 | 0.79 | LMNA (0.53) | PRKACARPS6KB1GSK3BROCK1ALDH1A1 | |
| SCHEMBL30897344 | 0.79 | PRKACA (0.52) | HDAC3HDAC1HDAC10HDAC6PRKACA | |
| SCHEMBL15956414 | 0.79 | LMNA (0.53) | PRKACARPS6KB1GSK3BROCK1ALDH1A1 | |
| SCHEMBL1708203 | 0.79 | HTT (0.60) | PRKACARPS6KB1GSK3BROCK1ALDH1A1 | |
| SCHEMBL979443 | 0.79 | HTT (0.60) | PRKACARPS6KB1GSK3BROCK1ALDH1A1 | |
| SCHEMBL5054186 | 0.76 | POLB (0.57) | PRKACARPS6KB1GSK3BROCK1ALDH1A1 | |
| SCHEMBL4714535 | 0.75 | VDR (0.53) | HDAC3HDAC1HDAC10HDAC6PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440295-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010144679-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-16 | — | — | WO | disclosed |