Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708106 | 0.87 | NPC1 (0.35) | NPC1RAB9AINSRIGF1RALDH1A1 | |
| SCHEMBL1708093 | 0.87 | NPC1 (0.38) | NPC1RAB9AALDH1A1LMNAMAPT | |
| SCHEMBL1708080 | 0.85 | NPC1 (0.35) | NPC1RAB9AINSRIGF1RALDH1A1 | |
| SCHEMBL1708150 | 0.85 | NPC1 (0.39) | NPC1RAB9AALDH1A1LMNAMAPT | |
| SCHEMBL1708139 | 0.85 | GFER (0.39) | NPC1RAB9AALDH1A1LMNAMAPT | |
| SCHEMBL1708036 | 0.84 | INSR (0.35) | NPC1RAB9AINSRIGF1RHTR2A | |
| SCHEMBL1708155 | 0.84 | NTRK1 (0.37) | NPC1RAB9AALDH1A1LMNAMAPT | |
| SCHEMBL1708081 | 0.84 | SCD (0.36) | NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL1708010 | 0.84 | NPC1 (0.36) | NPC1RAB9AALDH1A1LMNAMAPT | |
| SCHEMBL1708162 | 0.83 | MAPT (0.34) | NPC1RAB9AALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |