SCHEMBL1708162

SCHEMBL1708162

COc1nc2ccccc2n1-c1cccc(CNc2ccc3c(c2)OC(C)[C@H]3OC(C)=O)c1C

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.34
L3MBTL1 Q9Y468 3/20 0.34
KDM4E B2RXH2 2/20 0.34
TDP1 Q9NUW8 1/20 0.34
GPR55 Q9Y2T6 1/20 0.34
NPC1 O15118 3/20 0.34
RAB9A P51151 3/20 0.34
PDCD1 Q15116 1/20 0.34
CD274 Q9NZQ7 1/20 0.34
GAA P10253 4/20 0.32
PKM P14618 3/20 0.32
PTGS1 P23219 1/20 0.32
PTGS2 P35354 1/20 0.32
ALOX5 P09917 1/20 0.32
TSHR P16473 2/20 0.32
NTRK1 P04629 1/20 0.32
NTRK2 Q16620 1/20 0.32
MAPK1 P28482 1/20 0.32
VCP P55072 2/20 0.32
TP53 P04637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1708111 0.93 NPC1 (0.33) MAPTL3MBTL1KDM4ETDP1GPR55
SCHEMBL1708155 0.90 NTRK1 (0.37) MAPTL3MBTL1KDM4ETDP1NPC1
SCHEMBL1708631 0.90 NPC1 (0.35) MAPTL3MBTL1KDM4ETDP1GPR55
SCHEMBL1708072 0.89 LMNA (0.37) MAPTL3MBTL1NPC1RAB9AGAA
SCHEMBL1708613 0.88 ALDH1A1 (0.34) MAPTL3MBTL1NPC1RAB9APDCD1
SCHEMBL1708145 0.88 TSHR (0.33) MAPTL3MBTL1KDM4ETDP1GPR55
SCHEMBL1708148 0.86 MTNR1A (0.41) MAPTL3MBTL1KDM4ETDP1GPR55
SCHEMBL1708139 0.85 GFER (0.39) MAPTL3MBTL1KDM4ETDP1GPR55
SCHEMBL1708622 0.85 TSHR (0.35) MAPTL3MBTL1KDM4ETDP1GPR55
SCHEMBL1708298 0.84 PDE10A (0.33) MAPTL3MBTL1KDM4ETDP1GPR55

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2440541-A1 NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2012-04-18 EP disclosed
WO-2010143733-A1 NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-12-16 WO disclosed