Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGAV | P06756 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.42 |
| ▸ | ITGAL | P20701 | 1/20 | 0.42 |
| ▸ | SLC6A12 | P48065 | 5/20 | 0.37 |
| ▸ | SLC6A11 | P48066 | 5/20 | 0.37 |
| ▸ | SLC6A13 | Q9NSD5 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1067170 | 0.81 | HSD11B1 (0.61) | HSD11B1ITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL17082744 | 0.81 | HSD11B1 (0.47) | HSD11B1ITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL10660112 | 0.78 | HSD11B1 (0.39) | HSD11B1ITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL13369738 | 0.74 | ALDH1A1 (0.44) | HSD11B1ITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL15610164 | 0.74 | ALDH1A1 (0.44) | HSD11B1ITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL7859286 | 0.74 | HSD11B1 (0.58) | HSD11B1ITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL7046134 | 0.74 | HSD11B1 (0.58) | HSD11B1ITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL17082750 | 0.73 | HSD11B1 (0.58) | HSD11B1ITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL3754325 | 0.72 | HSD11B1 (0.56) | HSD11B1ITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL10248614 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054368-B1 | CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2015-09-16 | — | — | EP | disclosed |