Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 3/20 | 0.42 |
| ▸ | CDC25B | P30305 | 3/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | SNCA | P37840 | 2/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9915565 | 0.81 | MAPT (0.74) | MAPTMAPK1KDM4EALDH1A1CYP3A4 | |
| Lawsone SCHEMBL9136705 | 0.78 | MAPT (0.63) | MAPTMAPK1KDM4EALDH1A1CYP3A4 | |
| Lawsone SCHEMBL5826345 | 0.77 | MAPT (0.68) | MAPTMAPK1KDM4EALDH1A1CYP3A4 | |
| Lawsone SCHEMBL29350263 | 0.77 | MAPT (0.68) | MAPTMAPK1KDM4EALDH1A1CYP3A4 | |
| Lawsone SCHEMBL6849999 | 0.77 | MAPT (0.68) | MAPTMAPK1KDM4EALDH1A1CYP3A4 | |
| Lawsone SCHEMBL16541 | 0.77 | MAPT (0.68) | MAPTMAPK1KDM4EALDH1A1CYP3A4 | |
| Lawsone SCHEMBL6052709 | 0.76 | MAPT (0.65) | MAPTMAPK1KDM4EALDH1A1CYP3A4 | |
| Lawsone SCHEMBL6052722 | 0.76 | MAPT (0.65) | MAPTMAPK1KDM4EALDH1A1CYP3A4 | |
| Lawsone SCHEMBL6052663 | 0.76 | MAPT (0.65) | MAPTMAPK1KDM4EALDH1A1CYP3A4 | |
| Lawsone SCHEMBL918203 | 0.72 | MAPT (0.61) | MAPTMAPK1KDM4EALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848432-B1 | Pharmaceutical composition for the treatment or prevention of diseases involving obesity, diabetes, metabolic syndrome, neuro-degenerative diseases and mitochondria dysfunction diseases | MD BIOALPHA CO LTD (KR) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012047628-A2 | METHODS OF MANAGING BLOOD SUGAR LEVELS AND COMPOSITIONS RELATED THERETO | EMORY UNIVERSITY (US) | 2012-04-12 | — | — | WO | disclosed |