Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17086801 | 0.93 | HDAC1 (0.47) | HDAC6HDAC1HDAC4KCNH2HDAC8 | |
| SCHEMBL17078539 | 0.88 | HDAC6 (0.55) | HDAC6HDAC1HDAC4KCNH2KLK1 | |
| SCHEMBL17086795 | 0.83 | HDAC1 (0.40) | HIF1AEPAS1HDAC6HDAC1HDAC4 | |
| SCHEMBL17078835 | 0.81 | HDAC1 (0.58) | HDAC6HDAC1HDAC4KCNH2HDAC8 | |
| SCHEMBL17078684 | 0.79 | ROCK2 (0.43) | HDAC6HDAC1KLK1KLKB1 | |
| SCHEMBL17078973 | 0.78 | HDAC6 (0.71) | HIF1AEPAS1HDAC6HDAC1HDAC4 | |
| SCHEMBL20432679 | 0.78 | HDAC6 (0.71) | HIF1AEPAS1HDAC6HDAC1HDAC4 | |
| SCHEMBL17078812 | 0.77 | HDAC6 (0.54) | HDAC6HDAC1HDAC8 | |
| SCHEMBL20432795 | 0.77 | HDAC6 (0.54) | HDAC6HDAC1HDAC8 | |
| SCHEMBL20421030 | 0.75 | HDAC1 (0.58) | HDAC6HDAC1HDAC4KCNH2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015137750-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2015-09-17 | — | — | WO | disclosed |