Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 20/20 | 0.78 |
| ▸ | SLCO1B1 | Q9Y6L6 | 4/20 | 0.74 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.74 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.74 |
| ▸ | ABCC2 | Q92887 | 2/20 | 0.74 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.74 |
| ▸ | PPIB | P23284 | 11/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.72 |
| ▸ | PPIF | P30405 | 2/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.72 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.72 |
| ▸ | GMNN | O75496 | 1/20 | 0.72 |
| ▸ | USP2 | O75604 | 1/20 | 0.72 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16546031 | 1.00 | PPIA (0.78) | PPIASLCO1B1ABCB11ABCB1ABCC2 | |
| SCHEMBL15182917 | 1.00 | PPIA (0.78) | PPIASLCO1B1ABCB11ABCB1ABCC2 | |
| SCHEMBL15182919 | 1.00 | PPIA (0.78) | PPIASLCO1B1ABCB11ABCB1ABCC2 | |
| SCHEMBL15183399 | 0.99 | PPIA (0.77) | PPIASLCO1B1ABCB11ABCB1ABCC2 | |
| SCHEMBL19861427 | 0.99 | PPIA (0.77) | PPIASLCO1B1ABCB11ABCB1ABCC2 | |
| SCHEMBL15183393 | 0.97 | PPIA (0.74) | PPIASLCO1B1ABCB11ABCB1ABCC2 | |
| SCHEMBL19861430 | 0.96 | PPIA (0.73) | PPIASLCO1B1ABCB11ABCB1ABCC2 | |
| SCHEMBL1708969 | 0.96 | PPIA (0.75) | PPIASLCO1B1ABCB11ABCB1ABCC2 | |
| SCHEMBL1708946 | 0.96 | PPIA (0.72) | PPIASLCO1B1ABCB11ABCB1ABCC2 | |
| SCHEMBL16546034 | 0.96 | PPIA (0.72) | PPIASLCO1B1ABCB11ABCB1ABCC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9579385-B2 | Ophthalmic compositions comprising polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymers | ALLERGAN, INC. (US) | 2017-02-28 | — | — | US | disclosed |
| US-20170029469-A1 | CYCLOSPORIN ANALOGS | ALLERGAN, INC. | 2017-02-02 | — | — | US | disclosed |
| US-9493511-B2 | Cyclosporin analogs | ALLERGAN, INC. (US) | 2016-11-15 | — | — | US | disclosed |
| US-20140128329-A1 | OPHTHALMIC COMPOSITIONS COMPRISING POLYVINYL CAPROLACTAM-POLYVINYL ACETATE-POLYETHYLENE GLYCOL GRAFT COPOLYMERS | ALLERGAN, INC. (US) | 2014-05-08 | — | — | US | disclosed |
| US-20130157963-A1 | OPHTHALMIC COMPOSITIONS COMPRISING POLYVINYL CAPRALACTAM-POLYVINYL ACETATE-POLYETHYLENE GLYCOL GRAFT COPOLYMERS | ALLERGAN, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-20120088734-A1 | Cyclosporin Analogs | ALLERGAN, INC. (US) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130157963-A1 | OPHTHALMIC COMPOSITIONS COMPRISING POLYVINYL CAPRALACTAM-POLYVINYL ACETATE-POLYETHYLENE GLYCOL GRAFT COPOLYMERS | PDE6D, UACA, ADCYAP1R1 | PPIA 381/4885SLCO1B1 1771/4885ABCB11 3443/4885 |
| US-20120088734-A1 | Cyclosporin Analogs | CHP1, TSLP, PPP3R1 | PPIA 202/4885SLCO1B1 1324/4885ABCB11 2040/4885 |
| US-20170029469-A1 | CYCLOSPORIN ANALOGS | CHP1, TSLP, PPP3R1 | PPIA 202/4885SLCO1B1 1324/4885ABCB11 2040/4885 |
| US-20140128329-A1 | OPHTHALMIC COMPOSITIONS COMPRISING POLYVINYL CAPROLACTAM-POLYVINYL ACETATE-POLYETHYLENE GLYCOL GRAFT COPOLYMERS | PDE6D, PDE6C, UACA | PPIA 413/4885SLCO1B1 1716/4885ABCB11 2979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.