Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.49 |
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | GPR39 | O43194 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565550 | 1.00 | CRHR1 (0.49) | CRHR1CNR2NPY5RF10KDM4E | |
| SCHEMBL11936198 | 0.88 | CNR2 (0.37) | CRHR1CNR2NPY5R | |
| SCHEMBL11935300 | 0.88 | CNR2 (0.37) | CRHR1CNR2NPY5R | |
| SCHEMBL13564748 | 0.87 | BRD4 (0.38) | CRHR1CNR2NPY5RBRD4HTR6 | |
| SCHEMBL17090297 | 0.87 | BRD4 (0.38) | CRHR1CNR2NPY5RBRD4HTR6 | |
| SCHEMBL13438988 | 0.86 | CRHR1 (0.48) | CRHR1CNR2NPY5RKDM4E | |
| SCHEMBL13565514 | 0.86 | OPRD1 (0.43) | CRHR1CNR2NPY5RKDM4EBRD4 | |
| SCHEMBL11935248 | 0.86 | CRHR1 (0.50) | CRHR1CNR2 | |
| SCHEMBL13438951 | 0.86 | BRD4 (0.38) | CRHR1CNR2NPY5RBRD4 | |
| SCHEMBL17089962 | 0.86 | OPRD1 (0.43) | CRHR1CNR2NPY5RKDM4EBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |