Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.40 |
| ▸ | UQCRB | P14927 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565514 | 1.00 | OPRD1 (0.43) | OPRD1OPRK1CRHR1UQCRBHSD17B2 | |
| SCHEMBL17090297 | 0.87 | BRD4 (0.38) | CRHR1CNR2BRD4NPY5RPOLB | |
| SCHEMBL13564748 | 0.87 | BRD4 (0.38) | CRHR1CNR2BRD4NPY5RPOLB | |
| SCHEMBL13438951 | 0.86 | BRD4 (0.38) | CRHR1CNR2BRD4NPY5RPOLB | |
| SCHEMBL17090174 | 0.86 | CRHR1 (0.49) | CRHR1CNR2BRD4NPY5RKDM4E | |
| SCHEMBL13438930 | 0.86 | CRHR1 (0.50) | CRHR1CNR2POLB | |
| SCHEMBL11935248 | 0.86 | CRHR1 (0.50) | CRHR1CNR2POLB | |
| SCHEMBL13565550 | 0.86 | CRHR1 (0.49) | CRHR1CNR2BRD4NPY5RKDM4E | |
| SCHEMBL13462606 | 0.86 | BRD4 (0.38) | CRHR1CNR2BRD4NPY5RPOLB | |
| SCHEMBL17090296 | 0.85 | POLB (0.41) | CRHR1NPY5RPOLBALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |