Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 5/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | DRD3 | P35462 | 3/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565110 | 1.00 | TRPA1 (0.37) | TRPA1CNR2JAK2JAK1TYK2 | |
| SCHEMBL13565589 | 0.90 | JAK2 (0.35) | TRPA1CNR2JAK2JAK1TYK2 | |
| SCHEMBL17090385 | 0.90 | JAK2 (0.35) | TRPA1CNR2JAK2JAK1TYK2 | |
| SCHEMBL17090471 | 0.85 | CNR2 (0.49) | CNR2JAK2JAK1TYK2TGFBR1 | |
| SCHEMBL13565468 | 0.85 | CNR2 (0.49) | CNR2JAK2JAK1TYK2TGFBR1 | |
| SCHEMBL17090468 | 0.85 | CNR2 (0.49) | CNR2JAK2JAK1TYK2TGFBR1 | |
| SCHEMBL10133461 | 0.82 | ALDH1A1 (0.46) | KDM4EALDH1A1MAPTSMN1; SMN2TDP1 | |
| SCHEMBL12882403 | 0.82 | ALDH1A1 (0.46) | KDM4EALDH1A1MAPTSMN1; SMN2TDP1 | |
| SCHEMBL10114376 | 0.82 | ALDH1A1 (0.46) | KDM4EALDH1A1MAPTSMN1; SMN2TDP1 | |
| SCHEMBL14424750 | 0.82 | ALDH1A1 (0.46) | KDM4EALDH1A1MAPTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |