Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 9/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565589 | 1.00 | JAK2 (0.35) | JAK2JAK1TYK2TRPA1CNR2 | |
| SCHEMBL13565110 | 0.90 | TRPA1 (0.37) | JAK2JAK1TYK2TRPA1CNR2 | |
| SCHEMBL17090192 | 0.90 | TRPA1 (0.37) | JAK2JAK1TYK2TRPA1CNR2 | |
| SCHEMBL11941013 | 0.89 | GSK3A (0.35) | JAK2JAK1TYK2TRPA1CNR2 | |
| SCHEMBL11935093 | 0.87 | MAPT (0.45) | JAK2JAK1TYK2CNR2ALDH1A1 | |
| SCHEMBL13462791 | 0.83 | ALDH1A1 (0.37) | JAK2JAK1TYK2TRPA1CNR2 | |
| SCHEMBL13438947 | 0.83 | ALDH1A1 (0.37) | JAK2JAK1TYK2TRPA1CNR2 | |
| SCHEMBL11935259 | 0.83 | ALDH1A1 (0.37) | JAK2JAK1TYK2TRPA1CNR2 | |
| SCHEMBL13565425 | 0.82 | ALDH1A1 (0.41) | NPY5RALDH1A1KDM4EGAAMAPT | |
| SCHEMBL13565710 | 0.82 | HRH4 (0.39) | NPY5RADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |