Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.42 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565171 | 0.85 | AAK1 (0.41) | IMPDH2IMPDH1KMT2APOLBCYP3A4 | |
| SCHEMBL13565104 | 0.83 | TAAR1 (0.37) | KMT2APOLBCYP3A4MEN1KDM4E | |
| SCHEMBL17090361 | 0.83 | TAAR1 (0.37) | KMT2APOLBCYP3A4MEN1KDM4E | |
| SCHEMBL17090358 | 0.82 | TOP1 (0.39) | SYKALDH1A1KCNJ1NPY5R | |
| SCHEMBL13565095 | 0.82 | TOP1 (0.39) | SYKALDH1A1KCNJ1NPY5R | |
| SCHEMBL11941010 | 0.81 | IMPDH2 (0.41) | IMPDH2IMPDH1KMT2APOLBCYP3A4 | |
| SCHEMBL13439041 | 0.81 | IMPDH2 (0.41) | IMPDH2IMPDH1KMT2APOLBCYP3A4 | |
| SCHEMBL10114591 | 0.80 | NPY5R (0.52) | IMPDH2IMPDH1KMT2ASYKJAK3 | |
| SCHEMBL14424346 | 0.80 | NPY5R (0.52) | IMPDH2IMPDH1KMT2ASYKJAK3 | |
| SCHEMBL13565131 | 0.80 | CRHR1 (0.39) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |