Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CTSG | P08311 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17090501 | 0.88 | ADRB2 (0.46) | GRIA1HTR1ANPY5RADRB2ADRB3 | |
| SCHEMBL10113848 | 0.86 | HDAC6 (0.50) | HTR1ASMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL13565562 | 0.84 | GRIA1 (0.51) | GRIA1HTR1ANPY5RKMT2A | |
| SCHEMBL17090493 | 0.84 | TLR7 (0.40) | SLC7A5TLR7MTNR1AMTNR1BSYK | |
| SCHEMBL17090496 | 0.82 | KMT2A (0.48) | GRIA1HTR1ANPY5RMTNR1AMTNR1B | |
| SCHEMBL13565561 | 0.81 | GRIA1 (0.47) | GRIA1HTR1ANPY5RKMT2A | |
| SCHEMBL11935002 | 0.81 | SLC7A5 (0.47) | SLC7A5TLR7MTNR1AMTNR1BSYK | |
| SCHEMBL13565857 | 0.79 | GRIA1 (0.51) | GRIA1HTR1ANPY5RKMT2A | |
| SCHEMBL11935080 | 0.79 | HTR1A (0.50) | GRIA1HTR1ANPY5RSMN1; SMN2LMNA | |
| SCHEMBL11935049 | 0.79 | HTR1A (0.61) | GRIA1HTR1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |