Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | SELP | P16109 | 2/20 | 0.40 |
| ▸ | SELE | P16581 | 2/20 | 0.40 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.38 |
| ▸ | SELL | P14151 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17090495 | 0.88 | GRIA1 (0.43) | ADRB2ADRB3GRIA1HTR1ANPY5R | |
| SCHEMBL13565562 | 0.86 | GRIA1 (0.51) | GRIA1HTR1ANPY5RGRIA4HDAC11 | |
| SCHEMBL10113852 | 0.85 | HDAC6 (0.52) | HTR1ANR1H4SELPSELEHPSE | |
| SCHEMBL17089974 | 0.83 | NR1H4 (0.46) | ADRB2ADRB3PFKFB3NR1H4FABP4 | |
| SCHEMBL13565561 | 0.83 | GRIA1 (0.47) | GRIA1HTR1ANPY5RGRIA4 | |
| SCHEMBL13565857 | 0.81 | GRIA1 (0.51) | GRIA1HTR1ANPY5RGRIA4 | |
| SCHEMBL11935049 | 0.81 | HTR1A (0.61) | GRIA1HTR1AGRIA2 | |
| SCHEMBL11935080 | 0.81 | HTR1A (0.50) | GRIA1HTR1ANPY5R | |
| SCHEMBL17090498 | 0.81 | PKM (0.47) | GRIA1HTR1ANPY5R | |
| SCHEMBL13566030 | 0.80 | GRIA1 (0.61) | GRIA1HTR1ANPY5RGRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |