Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565324 | 1.00 | NPSR1 (0.36) | NPSR1HPGDMCOLN3NPY5RCRHR1 | |
| SCHEMBL17090355 | 0.87 | CRHR1 (0.42) | NPY5RCRHR1MEN1KMT2AALDH1A1 | |
| SCHEMBL13565190 | 0.87 | CRHR1 (0.42) | NPY5RCRHR1MEN1KMT2AALDH1A1 | |
| SCHEMBL13462871 | 0.86 | HPGD (0.38) | NPSR1HPGDMCOLN3NPY5RCRHR1 | |
| SCHEMBL13439231 | 0.86 | HPGD (0.38) | NPSR1HPGDMCOLN3NPY5RCRHR1 | |
| SCHEMBL17090128 | 0.86 | MEN1 (0.43) | NPY5RCRHR1CNR2CNR1MEN1 | |
| SCHEMBL13565746 | 0.86 | MEN1 (0.43) | NPY5RCRHR1CNR2CNR1MEN1 | |
| SCHEMBL13438995 | 0.86 | MAPK14 (0.46) | NPY5RCRHR1CNR2CNR1MEN1 | |
| SCHEMBL11935305 | 0.86 | MAPK14 (0.46) | NPY5RCRHR1CNR2CNR1MEN1 | |
| SCHEMBL17090516 | 0.84 | CRHR1 (0.47) | HPGDNPY5RCRHR1CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |