Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 4/20 | 0.35 |
| ▸ | JAK1 | P23458 | 11/20 | 0.34 |
| ▸ | JAK3 | P52333 | 11/20 | 0.34 |
| ▸ | JAK2 | O60674 | 6/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1285338 | 0.85 | SYK (0.48) | SYKGRM5JAK1JAK3JAK2 | |
| SCHEMBL1709139 | 0.73 | CYP1A2 (0.35) | CYP3A4CYP1A2CYP2D6MAPK1CYP2C19 | |
| SCHEMBL1286232 | 0.69 | SYK (0.43) | SYK | |
| SCHEMBL15759798 | 0.69 | NOS1 (0.44) | SYKGRM5CYP1A2TSHRNOS3 | |
| SCHEMBL16435084 | 0.69 | SYK (0.46) | SYKGRM5NOS3NOS1NOS2 | |
| SCHEMBL1709138 | 0.68 | GABRG2 (0.37) | JAK3JAK2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL11132639 | 0.66 | NOS1 (0.52) | SYKGRM5CYP1A2MAPK1TSHR | |
| SCHEMBL14651126 | 0.65 | SYK (1.00) | SYK | |
| SCHEMBL12846639 | 0.65 | GRM5 (0.36) | SYKGRM5 | |
| SCHEMBL1285628 | 0.63 | NOS1 (0.41) | SYKGRM5CYP1A2TSHRNOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088755-A1 | Novel Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088755-A1 | Novel Compounds | SLC26A4, F12, SLCO1B3 | SYK 4533/4885GRM5 2252/4885JAK1 2941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.