Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.48 |
| ▸ | OXTR | P30559 | 1/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1286789 | 0.76 | HPGD (0.53) | ALDH1A1HPGDTSHR | |
| SCHEMBL6198498 | 0.76 | ALDH1A1 (0.81) | POLBHSD17B10ALDH1A1HPGDAVPR2 | |
| SCHEMBL29463754 | 0.76 | ALDH1A1 (0.81) | POLBHSD17B10ALDH1A1HPGDAVPR2 | |
| SCHEMBL7348349 | 0.71 | AVPR2 (0.76) | MAPK1HSD17B10ALDH1A1HPGDRECQL | |
| Thiourea SCHEMBL15400235 | 0.71 | ALDH1A1 (0.70) | POLBMAPTMAPK1HSD17B10ALDH1A1 | |
| SCHEMBL17953083 | 0.70 | ALDH1A1 (0.62) | MAPTMAPK1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1709233 | 0.70 | ALDH1A1 (0.51) | MAPK1HSD17B10ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3136427 | 0.69 | POLB (0.73) | POLBHSD17B10ALDH1A1HPGDAVPR2 | |
| SCHEMBL2829456 | 0.69 | SMN1; SMN2 (0.77) | POLBMAPTMAPK1ALDH1A1HPGD | |
| SCHEMBL29353444 | 0.69 | SMN1; SMN2 (0.77) | POLBMAPTMAPK1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |