SCHEMBL17094641

SCHEMBL17094641

Cc1c(CO[Si](C)(C)C(C)(C)C)ccc(Cl)c1N

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 1/20 0.33
IDO1 P14902 1/20 0.30
MEN1 O00255 1/20 0.30
GAA P10253 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17094646 0.82 BACE1 (0.33) BACE1IDO1
SCHEMBL5465261 0.80 IDO1 (0.41) BACE1IDO1MEN1GAAKMT2A
SCHEMBL18149538 0.77 CYP3A4 (0.37) BACE1IDO1MEN1GAAKMT2A
SCHEMBL23213299 0.76 BACE1 (0.33) BACE1
SCHEMBL29796100 0.76 BACE1 (0.33) BACE1
SCHEMBL7234154 0.75 CYP3A4 (0.41) BACE1
SCHEMBL5743431 0.74 NOS2 (0.42) BACE1
SCHEMBL29704025 0.74 TKT (0.36) BACE1IDO1
SCHEMBL5744241 0.74 BACE1 (0.33) BACE1
SCHEMBL15389825 0.74 BACE1 (0.42) BACE1IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12398111-B2 Triazine compounds and pharmaceutical use thereof JAPAN TOBACCO INC. (JP) 2025-08-26 US disclosed
US-20230011968-A1 TRIAZINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC. (JP) 2023-01-12 US disclosed
US-20230011968-A1 TRIAZINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC. (JP) 2023-01-12 US disclosed
US-20200087266-A1 TRIAZINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC. (JP) 2020-03-19 US disclosed
EP-3456713-A1 PROCESS FOR THE PREPARATION OF TRIAZINE DERIVATIVES Japan Tobacco Inc. (JP) 2019-03-20 EP disclosed
EP-3109240-B1 TRIAZINE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES JAPAN TOBACCO INC (JP) 2018-10-24 EP disclosed
EP-3109240-A1 TRIAZINE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES Japan Tobacco, Inc. (JP) 2016-12-28 EP disclosed
US-20150266834-A1 TRIAZINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC. (JP) 2015-09-24 US disclosed
US-20150266834-A1 TRIAZINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC. (JP) 2015-09-24 US disclosed
US-20150266834-A1 TRIAZINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC. (JP) 2015-09-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150266834-A1 TRIAZINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF PTGIS, PTGS1, PTGES BACE1 348/4885IDO1 393/4885MEN1 59/4885
US-20200087266-A1 TRIAZINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF PTGIS, PTGS1, PTGES BACE1 348/4885IDO1 393/4885MEN1 59/4885
US-12398111-B2 Triazine compounds and pharmaceutical use thereof PTGIS, PTGS1, PTGES BACE1 348/4885IDO1 393/4885MEN1 59/4885
US-20230011968-A1 TRIAZINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF PTGIS, PTGS1, PTGES BACE1 348/4885IDO1 393/4885MEN1 59/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.