Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 2/20 | 0.67 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.67 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.67 |
| ▸ | ALPI | P09923 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | XIAP | P98170 | 1/20 | 0.58 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.58 |
| ▸ | LTA4H | P09960 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8494890 | 0.85 | ANPEP (0.69) | ANPEPRNPEPDNPEPALPIPKM | |
| SCHEMBL7347389 | 0.85 | ANPEP (0.69) | ANPEPRNPEPDNPEPALPIPKM | |
| SCHEMBL3114367 | 0.83 | ALPI (0.61) | ANPEPALPIPKMPTGS1XIAP | |
| SCHEMBL7413310 | 0.83 | ALPI (0.61) | ANPEPALPIPKMPTGS1XIAP | |
| SCHEMBL14973968 | 0.83 | ANPEP (0.55) | ANPEPRNPEPDNPEPALDH1A1MEN1 | |
| SCHEMBL12330216 | 0.83 | ANPEP (0.55) | ANPEPRNPEPDNPEPALDH1A1MEN1 | |
| SCHEMBL660504 | 0.82 | SLC7A5 (0.76) | ANPEPRNPEPDNPEPALPIPKM | |
| SCHEMBL660503 | 0.82 | SLC7A5 (0.76) | ANPEPRNPEPDNPEPALPIPKM | |
| SCHEMBL23015853 | 0.81 | ALDH1A1 (0.63) | ANPEPRNPEPDNPEPALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL3385081 | 0.81 | MMP8 (0.59) | ANPEPALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150299143-A1 | SUBSTITUTED TRIAZOLE AND IMIDAZOLE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-10-22 | — | — | US | claimed |
| US-20150299143-A1 | SUBSTITUTED TRIAZOLE AND IMIDAZOLE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-10-22 | — | — | US | disclosed |
| US-20150266920-A1 | MACROCYCLIC KETOAMIDE IMMUNOPROTEASOME INHIBITORS | HOFFMANN-LA ROCHE INC. | 2015-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150299143-A1 | SUBSTITUTED TRIAZOLE AND IMIDAZOLE COMPOUNDS | HDAC7, PSMB7, IKZF3 | ANPEP 3315/4885RNPEP 3218/4885DNPEP 1093/4885 |
| US-20150266920-A1 | MACROCYCLIC KETOAMIDE IMMUNOPROTEASOME INHIBITORS | PSMB7, PSMC2, PSMB8 | ANPEP 1090/4885RNPEP 477/4885DNPEP 423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.