Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | PNMT | P11086 | 4/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.40 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31394401 | 0.86 | BRD4 (0.46) | CMA1AHRPGRPNMTADRA2A | |
| Isobutyramide SCHEMBL17099457 | 0.85 | HPGD (0.39) | CMA1AHRPNMTADRA2AADRA2B | |
| SCHEMBL20617808 | 0.78 | HTR5A (0.43) | ADRA2AHPGDGFERHSD17B10ALDH1A1 | |
| SCHEMBL9082663 | 0.78 | CMA1 (0.43) | CMA1AHRPGRPNMTADRA2A | |
| SCHEMBL12280375 | 0.76 | PNMT (0.50) | CMA1AHRPNMTADRA2AADRA2B | |
| SCHEMBL15188950 | 0.73 | APP (0.44) | CMA1AHRPGRPNMTADRA2A | |
| SCHEMBL30512977 | 0.72 | HTT (0.58) | CMA1AHRPGRHPGDGFER | |
| SCHEMBL1119036 | 0.71 | GAA (0.46) | AHRPGRHPGDALDH1A1BRD4 | |
| SCHEMBL19155889 | 0.71 | HTR5A (0.42) | ADRA2AHPGDGFERHSD17B10ALDH1A1 | |
| SCHEMBL5328438 | 0.70 | AR (0.47) | PGRPNMTASIC3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015143376-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF CYSTIC FIBROSIS | NIVALIS THERAPEUTICS, INC. (US) | 2015-09-24 | — | — | WO | disclosed |