Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | HSD17B3 | P37058 | 3/20 | 0.35 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17099540 | 0.83 | FSHR (0.39) | FFAR4HSD17B3LMNAGFERKDM4E | |
| SCHEMBL17099539 | 0.80 | HTT (0.42) | SMN1; SMN2 | |
| SCHEMBL23123817 | 0.76 | ABHD6 (0.41) | NPC1RAB9ASMN1; SMN2HSD17B3ABHD6 | |
| SCHEMBL29789867 | 0.76 | ABHD6 (0.41) | NPC1RAB9ASMN1; SMN2HSD17B3ABHD6 | |
| SCHEMBL12036060 | 0.74 | FFAR4 (0.44) | NPC1RAB9ASMN1; SMN2FFAR4LMNA | |
| SCHEMBL30350644 | 0.74 | FFAR4 (0.44) | NPC1RAB9ASMN1; SMN2FFAR4LMNA | |
| SCHEMBL29209110 | 0.72 | OPRM1 (0.39) | SMN1; SMN2OPRM1OPRD1CYP1A2CYP3A4 | |
| SCHEMBL3450078 | 0.71 | RORC (0.39) | NPC1RAB9AABHD6HDAC1 | |
| SCHEMBL17099458 | 0.67 | HTR2A (0.43) | SMN1; SMN2HSD17B3LMNAPMP22NPSR1 | |
| SCHEMBL25959828 | 0.67 | KDM4E (0.43) | RAB9AHSD17B3ABHD6TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015143376-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF CYSTIC FIBROSIS | NIVALIS THERAPEUTICS, INC. (US) | 2015-09-24 | — | — | WO | disclosed |