Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.65 |
| ▸ | CA9 | Q16790 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | CNR2 | P34972 | 1/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25547142 | 0.87 | CA12 (0.83) | CA12CYP1A2CYP3A4ATMCA9 | |
| SCHEMBL17101704 | 0.85 | ALDH1A1 (0.61) | CA12CA9ALDH1A1LMNACYP19A1 | |
| SCHEMBL5651347 | 0.84 | KEAP1 (0.74) | CA12CYP1A2CYP3A4ATMCA9 | |
| SCHEMBL17101705 | 0.84 | KMT2A (0.59) | CA12CYP1A2CYP3A4ATMCA9 | |
| SCHEMBL17101738 | 0.84 | ALDH1A1 (0.70) | ALDH1A1LMNASMN1; SMN2HTTCYP19A1 | |
| SCHEMBL12030446 | 0.84 | ALDH1A1 (0.70) | ALDH1A1LMNASMN1; SMN2HTTCYP19A1 | |
| SCHEMBL26154030 | 0.83 | CA12 (0.71) | CA12CYP1A2CYP3A4ATMCA9 | |
| SCHEMBL17101780 | 0.82 | KEAP1 (0.61) | CA12CYP1A2CYP3A4ATMCA9 | |
| SCHEMBL4662819 | 0.82 | CA12 (0.87) | CA12CYP1A2CYP3A4ATMCA9 | |
| SCHEMBL17101677 | 0.82 | ALDH1A1 (0.66) | ALDH1A1LMNASMN1; SMN2HTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015140566-A1 | PYRAZOLO-PYRIMIDINES AS INHIBITORS OF BTK | REDX PHARMA PLC (GB) | 2015-09-24 | — | — | WO | disclosed |