Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | FBP1 | P09467 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17101792 | 0.84 | CA12 (0.65) | KMT2AALDH1A1CYP19A1MAPTCA12 | |
| SCHEMBL16660687 | 0.84 | ALDH1A1 (0.73) | KMT2AFBP1ALDH1A1CYP19A1OPRK1 | |
| SCHEMBL17101822 | 0.83 | HSD11B1 (0.61) | KMT2AFBP1ALDH1A1CYP19A1MAPT | |
| SCHEMBL17101683 | 0.83 | ALDH1A1 (0.64) | KMT2AALDH1A1CYP19A1MAPTHTT | |
| SCHEMBL14902026 | 0.80 | KMT2A (0.62) | KMT2AFBP1ALDH1A1CYP19A1OPRK1 | |
| SCHEMBL17101803 | 0.80 | CYP19A1 (0.66) | KMT2AALDH1A1CYP19A1OPRK1MAPT | |
| SCHEMBL17101675 | 0.80 | MEP1B (0.52) | KMT2AALDH1A1ATML3MBTL1HTT | |
| SCHEMBL17101703 | 0.80 | HTT (0.65) | KMT2AALDH1A1MAPTCYP3A4ATM | |
| SCHEMBL29285993 | 0.78 | CYP19A1 (0.63) | KMT2AALDH1A1CYP19A1MAPTHTT | |
| SCHEMBL30989152 | 0.78 | CYP19A1 (0.63) | KMT2AALDH1A1CYP19A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015140566-A1 | PYRAZOLO-PYRIMIDINES AS INHIBITORS OF BTK | REDX PHARMA PLC (GB) | 2015-09-24 | — | — | WO | disclosed |