Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 5/20 | 0.40 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA9 | Q16790 | 4/20 | 0.40 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3903913 | 0.87 | PAOX (0.44) | CA2CA1CA9PAOXHTR7 | |
| SCHEMBL13974361 | 0.81 | HRH3 (0.37) | CA2CA1 | |
| SCHEMBL3218443 | 0.81 | L3MBTL1 (0.41) | CA2CA1 | |
| SCHEMBL2485662 | 0.79 | L3MBTL1 (0.45) | CA2CA1LMNASMN1; SMN2 | |
| SCHEMBL12015831 | 0.79 | PAOX (0.39) | CA2CA1CA9PAOXLMNA | |
| SCHEMBL13485582 | 0.79 | PAOX (0.39) | CA2CA1CA9PAOXHTR7 | |
| SCHEMBL3607141 | 0.77 | PAOX (0.42) | CA2CA1CA9PAOXALOX15 | |
| SCHEMBL17850520 | 0.77 | PAOX (0.38) | CA2CA1CA9PAOXLMNA | |
| SCHEMBL18803169 | 0.77 | PAOX (0.38) | CA2CA1CA9PAOXHTR7 | |
| Hydrochloric Acid SCHEMBL11534273 | 0.77 | L3MBTL1 (0.43) | CA2CA1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3119763-A1 | NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | Iteos Therapeutics (BE) | 2017-01-25 | — | — | EP | disclosed |
| WO-2015140717-A1 | NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | ITEOS THERAPEUTICS (BE) | 2015-09-24 | — | — | WO | disclosed |