Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1724729 | 0.86 | DDB1 (0.48) | ALDH1A1SMN1; SMN2HTTMMP13 | |
| SCHEMBL1724175 | 0.81 | CA12 (0.38) | ALDH1A1SMN1; SMN2HAO1MCOLN3TSHR | |
| SCHEMBL2150725 | 0.76 | OPRM1 (0.40) | ALDH1A1SMN1; SMN2POLBHAO1HTT | |
| SCHEMBL1710420 | 0.75 | HAO1 (0.37) | RAB9APOLBHAO1NPC1TSHR | |
| SCHEMBL1710533 | 0.73 | RAB9A (0.49) | ALDH1A1SMN1; SMN2KDM4ERAB9APOLB | |
| Bicarbonate SCHEMBL15225927 | 0.73 | RAB9A (0.54) | ALDH1A1SMN1; SMN2RAB9APOLBNPC1 | |
| SCHEMBL2150730 | 0.73 | NPSR1 (0.57) | ALDH1A1SMN1; SMN2KDM4ERAB9APOLB | |
| SCHEMBL15226077 | 0.72 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2KDM4ERAB9APOLB | |
| SCHEMBL1710586 | 0.71 | OPRM1 (0.43) | ALDH1A1SMN1; SMN2RAB9APOLBKMT2A | |
| SCHEMBL1710552 | 0.71 | POLB (0.36) | ALDH1A1SMN1; SMN2KDM4ERAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344451-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010028088-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2010-03-11 | — | — | WO | disclosed |