Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.30 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1710469 | 0.92 | PRKCA (0.38) | PRKCABTN3A1POLBGAANPSR1 | |
| SCHEMBL9348634 | 0.86 | PRKCA (0.44) | PRKCABTN3A1POLBGAANPSR1 | |
| SCHEMBL5445288 | 0.79 | PRKCA (0.43) | PRKCABTN3A1POLBGAANPSR1 | |
| SCHEMBL2386487 | 0.74 | SERPINE1 (0.35) | — | |
| SCHEMBL367694 | 0.73 | — | — | |
| SCHEMBL13686650 | 0.73 | PRKCA (0.39) | PRKCABTN3A1POLBGAANPSR1 | |
| SCHEMBL30669879 | 0.73 | PRKCA (0.44) | PRKCABTN3A1POLBGAANPSR1 | |
| SCHEMBL1204159 | 0.73 | ALDH1A1 (0.40) | GAA | |
| SCHEMBL5493183 | 0.71 | — | — | |
| SCHEMBL24883882 | 0.71 | PRKCA (0.38) | PRKCAPOLBGAANPSR1CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344472-A1 | ISOQUINOLINONE DERIVATIVES | AstraZeneca AB (SE) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010039079-A1 | ISOQUINOLINONE DERIVATIVES | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |