Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 19/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSH | P09668 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17106933 | 1.00 | CTSK (0.65) | CTSKPOLBCTSLCTSBCTSH | |
| SCHEMBL17106924 | 1.00 | CTSK (0.65) | CTSKPOLBCTSLCTSBCTSH | |
| SCHEMBL17106932 | 1.00 | CTSK (0.65) | CTSKPOLBCTSLCTSBCTSH | |
| SCHEMBL14104859 | 0.89 | CTSK (0.52) | CTSKPOLBCTSS | |
| SCHEMBL7439028 | 0.88 | CTSK (0.53) | CTSKCTSS | |
| SCHEMBL26436628 | 0.85 | CTSK (0.79) | CTSKPOLBCTSLCTSBCTSH | |
| SCHEMBL8354664 | 0.85 | CTSK (0.48) | CTSKPOLBCTSS | |
| SCHEMBL4820525 | 0.85 | POLB (0.67) | CTSKPOLB | |
| SCHEMBL5639478 | 0.85 | POLB (0.67) | CTSKPOLB | |
| SCHEMBL4820530 | 0.85 | POLB (0.67) | CTSKPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150274777-A1 | KETOAMIDE IMMUNOPROTEASOME INHIBITORS | HOFFMANN-LA ROCHE INC. | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274777-A1 | KETOAMIDE IMMUNOPROTEASOME INHIBITORS | PSMB7, PSMB5, PSMC2 | CTSK 114/4885POLB 1457/4885CTSL 554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.