Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14147722 | 1.00 | LMNA (0.61) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL13314743 | 1.00 | LMNA (0.61) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL13893284 | 1.00 | LMNA (0.61) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL18744680 | 0.97 | TDP1 (0.63) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL810658 | 0.97 | TDP1 (0.63) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL3138410 | 0.97 | TDP1 (0.63) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL14147721 | 0.94 | LMNA (0.54) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL13296277 | 0.94 | LMNA (0.54) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL17108622 | 0.94 | LMNA (0.54) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL2991748 | 0.94 | LMNA (0.54) | LMNAL3MBTL1TDP1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015140527-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2015-09-24 | — | — | WO | disclosed |