Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14147722 | 1.00 | LMNA (0.61) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL17108604 | 1.00 | LMNA (0.61) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL13893284 | 1.00 | LMNA (0.61) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL18744680 | 0.97 | TDP1 (0.63) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL810658 | 0.97 | TDP1 (0.63) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL3138410 | 0.97 | TDP1 (0.63) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL14147721 | 0.94 | LMNA (0.54) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL13296277 | 0.94 | LMNA (0.54) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL17108622 | 0.94 | LMNA (0.54) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL2991748 | 0.94 | LMNA (0.54) | LMNAL3MBTL1TDP1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230399326-A1 | PYRAZOLE COMPOUNDS, FORMULATIONS THEREOF, AND A METHOD FOR USING THE COMPOUNDS AND/OR FORMULATIONS | RIGEL PHARMACEUTICALS, INC. (US) | 2023-12-14 | — | — | US | disclosed |
| US-11801254-B2 | Pharmaceutical compositions and methods of making pharmaceutical compositions comprising 2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate | AEROMICS, INC. (US) | 2023-10-31 | — | — | US | disclosed |
| US-11649222-B2 | Compounds | UNIVERSITETET I OSLO (NO) | 2023-05-16 | — | — | US | disclosed |
| US-20210214298-A1 | DEOXYDEHYDRATION OF SUGAR DERIVATIVES | UNIV CALIFORNIA (US) | 2021-07-15 | — | — | US | disclosed |
| US-10005752-B2 | Anticancer agent | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2018-06-26 | — | — | US | disclosed |
| US-9975856-B2 | Process for the preparation of (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid | GENENTECH, INC. (US) | 2018-05-22 | — | — | US | disclosed |
| US-20180066113-A9 | AMINOSILOXANE POLYMER AND METHOD OF FORMING | DOW SILICONES CORPORATION | 2018-03-08 | — | — | US | disclosed |
| US-20170362237-A1 | WATER SOLUBLE SALTS OF ALDOSE REDUCTASE INHIBITORS FOR TREATMENT OF DIABETIC COMPLICATIONS | MYLARI BANAVARA L (US) | 2017-12-21 | — | — | US | disclosed |
| US-9783503-B2 | Crystalline forms of an estrogen receptor modulator | GENENTECH, INC. (US) | 2017-10-10 | — | — | US | disclosed |
| US-9777066-B2 | Pharmaceutical compositions containing sc(Fv)2 | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2017-10-03 | — | — | US | disclosed |
| US-20140200246-A1 | COMPOUNDS FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH DGAT1 ACTIVITY | NOVARTIS AG (CH) | 2014-07-17 | — | — | US | disclosed |
| US-20140140953-A1 | SALTS OF BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION METHOD AND USE THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2014-05-22 | — | — | US | disclosed |
| US-8642637-B2 | Salts of bicyclo-substituted pyrazolon azo derivatives, preparation method and use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2014-02-04 | — | — | US | disclosed |
| US-20140010762-A1 | IMAGING AGENTS | CHROMA THERAPEUTICS LTD (GB) | 2014-01-09 | — | — | US | disclosed |
| US-8487126-B2 | Process for preparation of diethylenetriaminepentaacetic acid derivative, and diethylenetriaminepentaacetic acid derivative | THE UNIVERSITY OF TOKUSHIMA (JP) | 2013-07-16 | — | — | US | disclosed |
| US-20120203027-A1 | PROCESS FOR PREPARATION OF DIETHYLENETRIAMINEPENTAACETIC ACID DERIVATIVE, AND DIETHYLENETRIAMINEPENTAACETIC ACID DERIVATIVE | THE UNIVERSITY OF TOKUSHIMA (JP) | 2012-08-09 | — | — | US | disclosed |
| US-20120164102-A1 | SALTS OF BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION METHOD AND USE THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2012-06-28 | — | — | US | disclosed |
| US-20120077777-A1 | NGCYCLOARTANONE DERIVATIVES WITH ANTICANCER ACTIVITY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2012-03-29 | — | — | US | disclosed |
| US-7732416-B2 | For protecting plants against parasitic feeding pests; also against the infestation of pets, especially cats and dogs, by fleas, ticks and nematodes; pesticides for crop protection | MERIAL LIMITED (US) | 2010-06-08 | — | — | US | disclosed |
| US-7605134-B2 | Pesticides | MERIAL LIMITED (US) | 2009-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11801254-B2 | Pharmaceutical compositions and methods of making pharmaceutical compositions comprising 2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate | PLCG2, DCTPP1, PLCG1 | LMNA 4092/4885L3MBTL1 4836/4885TDP1 1488/4885 |
| US-10005752-B2 | Anticancer agent | TP53, NTPCR, NQO1 | LMNA 1792/4885L3MBTL1 2987/4885TDP1 1143/4885 |
| US-20230399326-A1 | PYRAZOLE COMPOUNDS, FORMULATIONS THEREOF, AND A METHOD FOR USING THE COMPOUNDS AND/OR FORMULATIONS | IRAK1, IRAK3, IRAK2 | LMNA 2272/4885L3MBTL1 4121/4885TDP1 618/4885 |
| US-20120077777-A1 | NGCYCLOARTANONE DERIVATIVES WITH ANTICANCER ACTIVITY | PKD1, NME1, NGLY1 | LMNA 660/4885L3MBTL1 4727/4885TDP1 2893/4885 |
| US-11649222-B2 | Compounds | SLC30A6, SLC39A11, SLC39A3 | LMNA 1307/4885L3MBTL1 277/4885TDP1 4608/4885 |
| US-20120203027-A1 | PROCESS FOR PREPARATION OF DIETHYLENETRIAMINEPENTAACETIC ACID DERIVATIVE, AND DIETHYLENETRIAMINEPENTAACETIC ACID DERIVATIVE | ETV6, ALAD, GART | LMNA 3000/4885L3MBTL1 1798/4885TDP1 3327/4885 |
| US-20210214298-A1 | DEOXYDEHYDRATION OF SUGAR DERIVATIVES | GCK, G6PD, SLC2A4 | LMNA 3876/4885L3MBTL1 3753/4885TDP1 2517/4885 |
| US-20180066113-A9 | AMINOSILOXANE POLYMER AND METHOD OF FORMING | HRH3, H1-2, H1-0 | LMNA 1867/4885L3MBTL1 1784/4885TDP1 3702/4885 |
| US-20140010762-A1 | IMAGING AGENTS | CES1, CES2, NCEH1 | LMNA 2970/4885L3MBTL1 1965/4885TDP1 808/4885 |
| US-20170362237-A1 | WATER SOLUBLE SALTS OF ALDOSE REDUCTASE INHIBITORS FOR TREATMENT OF DIABETIC COMPLICATIONS | ALDOA, AKR1C2, AKR1B1 | LMNA 3117/4885L3MBTL1 2446/4885TDP1 3309/4885 |
| US-20140140953-A1 | SALTS OF BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION METHOD AND USE THEREOF | THPO, MPL, TEK | LMNA 3753/4885L3MBTL1 4883/4885TDP1 3874/4885 |
| US-20140200246-A1 | COMPOUNDS FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH DGAT1 ACTIVITY | DGAT1, DGAT2, GBA1 | LMNA 1903/4885L3MBTL1 454/4885TDP1 902/4885 |
| US-20120164102-A1 | SALTS OF BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION METHOD AND USE THEREOF | THPO, MPL, TEK | LMNA 3753/4885L3MBTL1 4883/4885TDP1 3874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.