Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14147722 | 1.00 | LMNA (0.61) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL17108604 | 1.00 | LMNA (0.61) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL13314743 | 1.00 | LMNA (0.61) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL18744680 | 0.97 | TDP1 (0.63) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL810658 | 0.97 | TDP1 (0.63) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL3138410 | 0.97 | TDP1 (0.63) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL14147721 | 0.94 | LMNA (0.54) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL13296277 | 0.94 | LMNA (0.54) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL17108622 | 0.94 | LMNA (0.54) | LMNAL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL2991748 | 0.94 | LMNA (0.54) | LMNAL3MBTL1TDP1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190308943-A1 | 3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS | PARION SCIENCES, INC. (US) | 2019-10-10 | — | — | US | disclosed |
| CN-110036148-A | Electret fiber sheet material | 东丽株式会社 | 2019-07-19 | — | — | CN | disclosed |
| US-20170327541-A1 | METHODS FOR SYNTHESIZING alpha4ß7 PEPTIDE ANTAGONISTS | PROTAGONIST THERAPEUTICS, INC. | 2017-11-16 | — | — | US | disclosed |
| US-20170166673-A1 | HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF | ALCON INC. (CH) | 2017-06-15 | — | — | US | disclosed |
| US-9629924-B2 | Conjugates of CC-1065 analogs and bifunctional linkers | SYNTARGA BV (NL) | 2017-04-25 | — | — | US | disclosed |
| US-9592233-B2 | Pharmaceutical combination drug | BORYUNG PHARMACEUTICAL CO., LTD. (KR) | 2017-03-14 | — | — | US | disclosed |
| US-9329479-B2 | Lithographic printing plate precusor | AGFA GRAPHICS NV (BE) | 2016-05-03 | — | — | US | disclosed |
| US-20160022679-A1 | PHARMACEUTICAL COMBINATION DRUG | BORYUNG PHARMACEUTICAL CO., LTD. (KR) | 2016-01-28 | — | — | US | disclosed |
| WO-2015140527-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2015-09-24 | — | — | WO | disclosed |
| US-20150168837-A1 | LITHOGRAPHIC PRINTING PLATE PRECUSOR | ECO3 BV (BE) | 2015-06-18 | — | — | US | disclosed |
| US-8501242-B2 | Methods and compositions for treating neoplasia | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2013-08-06 | — | — | US | disclosed |
| US-20120270911-A1 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERRITHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS | FERROKIN BIOSCIENCES, INC. (US) | 2012-10-25 | — | — | US | disclosed |
| US-20120202857-A1 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERRITHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS | FERROKIN BIOSCIENCES, INC. (US) | 2012-08-09 | — | — | US | disclosed |
| US-20120156212-A1 | METHODS AND COMPOSITIONS FOR TREATING NEOPLASIA | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION | 2012-06-21 | — | — | US | disclosed |
| US-20120129147-A1 | METHOD OF PREPARING CONTROLS FOR GLYCATED HEMOGLOBIN S-A1C DERIVED FROM HEALTHY BLOOD CELLS | STRECK, INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-20120122073-A1 | CIS DI-AHL MODIFIED CONTROLS FOR GLYCATED HEMOGLOBIN S-A1C DERIVED FROM HEALTHY BLOOD CELLS | STRECK, INC. (US) | 2012-05-17 | — | — | US | disclosed |
| CN-101484458-B | Dibenzylidene sorbitol (dbs)-based compounds, compositions and methods for using such compounds | MILLIKEN & CO | 2011-10-19 | — | — | CN | disclosed |
| US-20110160257-A1 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERROTHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS | FERROKIN BIOSCIENCES, INC. (US) | 2011-06-30 | — | — | US | disclosed |
| US-20110105428-A1 | HYDROLYSIS RESISTANT ORGANOMODIFIED SILYLATED IONIC SURFACTANTS | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2011-05-05 | — | — | US | disclosed |
| CN-101484458-A | Dibenzylidene sorbitol (DBS)-based compounds, compositions and methods for using such compounds | MILLIKEN & CO (US) | 2009-07-15 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022679-A1 | PHARMACEUTICAL COMBINATION DRUG | PCSK9, PCSK6, DPP9 | LMNA 802/4885L3MBTL1 4589/4885TDP1 2096/4885 |
| US-20110160257-A1 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERROTHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS | SLC39A14, SLC40A1, SLC39A11 | LMNA 2758/4885L3MBTL1 247/4885TDP1 2149/4885 |
| US-20110105428-A1 | HYDROLYSIS RESISTANT ORGANOMODIFIED SILYLATED IONIC SURFACTANTS | MLNR, SSTR3, FOXM1 | LMNA 1699/4885L3MBTL1 1177/4885TDP1 4499/4885 |
| US-20120202857-A1 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERRITHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS | SLC39A14, SLC40A1, SLC39A11 | LMNA 2510/4885L3MBTL1 271/4885TDP1 2011/4885 |
| US-20120270911-A1 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERRITHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS | SLC39A14, SLC40A1, SLC39A11 | LMNA 2510/4885L3MBTL1 271/4885TDP1 2011/4885 |
| US-20190308943-A1 | 3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS | CFTR, SCNN1B, SCN5A | LMNA 1942/4885L3MBTL1 4622/4885TDP1 3894/4885 |
| US-20120156212-A1 | METHODS AND COMPOSITIONS FOR TREATING NEOPLASIA | TYMS, UNG, TYMP | LMNA 1559/4885L3MBTL1 2853/4885TDP1 169/4885 |
| US-20170327541-A1 | METHODS FOR SYNTHESIZING alpha4ß7 PEPTIDE ANTAGONISTS | PSMA7, PSMA4, IL4 | LMNA 2652/4885L3MBTL1 2637/4885TDP1 3628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.