Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | RHEB | Q15382 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12271513 | 0.83 | HRH4 (0.58) | HRH4PIN1EGLN1DHODHRHEB | |
| SCHEMBL18554546 | 0.81 | RHEB (0.42) | HRH4PIN1EGLN1KDM4EHPGD | |
| SCHEMBL31748504 | 0.76 | EGLN1 (0.44) | HRH4PIN1EGLN1DHODHRHEB | |
| SCHEMBL6988197 | 0.73 | EGLN1 (0.53) | PIN1EGLN1DHODHKDM4EHPGD | |
| SCHEMBL17276058 | 0.73 | MMP12 (0.44) | PTGER4ALDH1A1 | |
| SCHEMBL9589931 | 0.69 | PIN1 (0.47) | HRH4PIN1EGLN1KDM4EALDH1A1 | |
| SCHEMBL30212541 | 0.69 | KDM4E (0.49) | PTGER4KDM4EHPGDALDH1A1NFKB1 | |
| SCHEMBL8952887 | 0.68 | KDM4E (0.62) | DHODHKDM4EHPGD | |
| SCHEMBL7646 | 0.68 | KDM4E (0.46) | HRH4PIN1EGLN1DHODHKDM4E | |
| SCHEMBL17092653 | 0.68 | EGLN1 (0.55) | HRH4PIN1EGLN1RHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3009424-B1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2017-12-20 | — | — | EP | disclosed |
| US-9428501-B2 | Bicyclic nitrogen-containing aromatic heterocyclic amide compound | ASTELLAS PHARMA INC. (JP) | 2016-08-30 | — | — | US | disclosed |
| US-9428501-B2 | Bicyclic nitrogen-containing aromatic heterocyclic amide compound | ASTELLAS PHARMA INC. (JP) | 2016-08-30 | — | — | US | disclosed |
| EP-3009424-A1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2016-04-20 | — | — | EP | disclosed |
| US-20150266869-A1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2015-09-24 | — | — | US | disclosed |
| US-20150266869-A1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2015-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266869-A1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | PIK3CA, SLC16A3, MCTS1 | HRH4 695/4885PIN1 2598/4885EGLN1 1892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.