Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 2/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | PRKDC | P78527 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1711113 | 0.89 | PDK2 (0.44) | PDK2ALKMAPTKDM4EALDH1A1 | |
| SCHEMBL1710808 | 0.85 | ALK (0.42) | PDK2ALKPRKDCPIK3CAMAPT | |
| SCHEMBL10018191 | 0.81 | PDK2 (0.47) | PDK2ALKPRKDCPIK3CAPIK3CD | |
| SCHEMBL1711096 | 0.79 | PRKDC (0.40) | ALKPRKDCMAPTKDM4EALDH1A1 | |
| SCHEMBL1711119 | 0.78 | CHEK1 (0.41) | PDK2ALKPRKDCMAPTKDM4E | |
| SCHEMBL1711185 | 0.78 | ALK (0.40) | PDK2ALKPRKDCPIK3CAMAPT | |
| SCHEMBL15449609 | 0.78 | PDK2 (0.40) | PDK2PRKDCPIK3CAMAPTKDM4E | |
| SCHEMBL24605103 | 0.76 | PDK2 (0.43) | PDK2ALKPRKDCPIK3CAPIK3CD | |
| SCHEMBL15452246 | 0.75 | PDK2 (0.38) | PDK2PRKDCPIK3CAPIK3CDPIK3CB | |
| SCHEMBL10049683 | 0.75 | PDK2 (0.43) | PDK2ALKPRKDCPIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606274-B9 | INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL INC (US) | 2019-01-16 | — | — | EP | claimed |
| EP-1606274-B1 | INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL INC (US) | 2018-08-08 | — | — | EP | claimed |
| EP-2345647-A2 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL, INC. (US) | 2011-07-20 | — | — | EP | claimed |
| US-7517982-B2 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2009-04-14 | — | — | US | claimed |
| US-20070155964-A1 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | TRANSITIONS OPTICAL LIMITED (IE) | 2007-07-05 | — | — | US | claimed |
| US-20040185255-A1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL LIMITED (IE) | 2004-09-23 | — | — | US | claimed |
| EP-1606274-B9 | INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL INC (US) | 2019-01-16 | — | — | EP | disclosed |
| EP-1606274-B1 | INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL INC (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-2345648-B1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL INC (US) | 2012-10-24 | — | — | EP | disclosed |
| EP-2345648-A1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL, INC. (US) | 2011-07-20 | — | — | EP | disclosed |
| EP-2345647-A2 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL, INC. (US) | 2011-07-20 | — | — | EP | disclosed |
| US-7557208-B2 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2009-07-07 | — | — | US | disclosed |
| US-7517982-B2 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2009-04-14 | — | — | US | disclosed |
| US-20090062533-A1 | NAPHTHOLS USEFUL FOR PREPARING INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2009-03-05 | — | — | US | disclosed |
| US-7262295-B2 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-20070155964-A1 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | TRANSITIONS OPTICAL LIMITED (IE) | 2007-07-05 | — | — | US | disclosed |
| EP-1606274-A1 | INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL, INC. (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2005090327-A1 | INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL, INC. (US) | 2005-09-29 | — | — | WO | disclosed |
| US-20040185255-A1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL LIMITED (IE) | 2004-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040185255-A1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | IPO4, NPM1, PPOX | PDK2 3531/4885ALK 3416/4885PRKDC 4372/4885 |
| US-20070155964-A1 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | IPO5, IPO4, NQO1 | PDK2 2215/4885ALK 3220/4885PRKDC 4801/4885 |
| US-20090062533-A1 | NAPHTHOLS USEFUL FOR PREPARING INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS | IPO5, IPO4, NQO1 | PDK2 2215/4885ALK 3220/4885PRKDC 4801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.