Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1711809 | 1.00 | CHRM2 (0.42) | CHRM2CHRM1CHRM3NR1H2HSD11B1 | |
| SCHEMBL26046497 | 1.00 | CHRM2 (0.42) | CHRM2CHRM1CHRM3NR1H2HSD11B1 | |
| SCHEMBL12275013 | 1.00 | CHRM2 (0.42) | CHRM2CHRM1CHRM3NR1H2HSD11B1 | |
| SCHEMBL1711301 | 1.00 | CHRM2 (0.42) | CHRM2CHRM1CHRM3NR1H2HSD11B1 | |
| SCHEMBL6097554 | 1.00 | CHRM2 (0.42) | CHRM2CHRM1CHRM3NR1H2HSD11B1 | |
| SCHEMBL24267673 | 0.76 | HSD11B1 (0.41) | CHRM2CHRM1CHRM3NR1H2HSD11B1 | |
| SCHEMBL10516953 | 0.75 | PDE4B (0.40) | CHRM2CHRM1CHRM3NR1H2HSD11B1 | |
| SCHEMBL12955029 | 0.73 | CHRM2 (0.40) | CHRM2CHRM1CHRM3NR1H2HSD11B1 | |
| SCHEMBL12954976 | 0.73 | CHRM2 (0.40) | CHRM2CHRM1CHRM3NR1H2HSD11B1 | |
| SCHEMBL25201897 | 0.73 | CHRM2 (0.44) | CHRM2CHRM1CHRM3NR1H2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263629-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | TARGACEPT, INC. (US) | 2011-10-27 | — | — | US | disclosed |
| EP-2344496-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | Targacept Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010028033-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | TARGACEPT, INC. (US) | 2010-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263629-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | CHRNA2, CHRNA10, CHRNA5 | CHRM2 19/4885CHRM1 20/4885CHRM3 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.