Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 3/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 10/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17112620 | 1.00 | KCNK3 (0.42) | KCNK3KCNK9NR1H2TBK1PRMT5 | |
| SCHEMBL16961993 | 0.82 | ENPP2 (0.43) | NR1H2GPR119ATXN2 | |
| SCHEMBL16962692 | 0.82 | ENPP2 (0.43) | NR1H2GPR119ATXN2 | |
| SCHEMBL16961995 | 0.82 | ENPP2 (0.43) | NR1H2GPR119ATXN2 | |
| SCHEMBL29455198 | 0.81 | TACR1 (0.40) | NR1H2NAMPT | |
| SCHEMBL21321753 | 0.79 | HRH4 (0.34) | — | |
| SCHEMBL29455217 | 0.79 | SSTR4 (0.44) | GPR119NAMPT | |
| SCHEMBL17311070 | 0.78 | GPR119 (0.43) | GPR119 | |
| SCHEMBL17310828 | 0.78 | GPR119 (0.43) | GPR119 | |
| SCHEMBL17310827 | 0.78 | GPR119 (0.43) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122750-A1 | BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2017-02-01 | — | — | EP | disclosed |
| WO-2015144605-A1 | BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-10-01 | — | — | WO | disclosed |