Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 10/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 10/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 10/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.56 |
| ▸ | CHRNB3 | Q05901 | 5/20 | 0.47 |
| ▸ | CHRNA6 | Q15825 | 5/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3233321 | 0.86 | CHRNB2 (0.47) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL21891883 | 0.75 | CHRNB2 (0.50) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL1463858 | 0.72 | CHRNB2 (1.00) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL31630855 | 0.70 | CHRNB2 (0.46) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL10140410 | 0.68 | CHRNB2 (0.56) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL10196622 | 0.67 | CHRNB2 (0.59) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL21846690 | 0.67 | HRH3 (0.47) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL11778251 | 0.67 | HSD11B1 (0.60) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| SCHEMBL26124395 | 0.66 | CHRNB2 (0.48) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL24127299 | 0.66 | MEN1 (0.37) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263629-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | TARGACEPT, INC. (US) | 2011-10-27 | — | — | US | claimed |
| EP-2344496-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | Targacept Inc. (US) | 2011-07-20 | — | — | EP | claimed |
| WO-2010028033-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | TARGACEPT, INC. (US) | 2010-03-11 | — | — | WO | claimed |
| US-20110263629-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | TARGACEPT, INC. (US) | 2011-10-27 | — | — | US | disclosed |
| US-20110263629-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | TARGACEPT, INC. (US) | 2011-10-27 | — | — | US | disclosed |
| US-20110263629-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | TARGACEPT, INC. (US) | 2011-10-27 | — | — | US | disclosed |
| EP-2344496-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | Targacept Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010028033-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | TARGACEPT, INC. (US) | 2010-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263629-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | CHRNA2, CHRNA10, CHRNA5 | CHRNB2 7/4885CHRNA3 4/4885CHRNA4 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.