Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLRMT | O00411 | 1/20 | 0.40 |
| ▸ | P2RY2 | P41231 | 5/20 | 0.39 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.39 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.34 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.32 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17106746 | 1.00 | POLRMT (0.40) | POLRMTP2RY2P2RY1P2RY11P2RX1 | |
| SCHEMBL19412734 | 0.87 | POLRMT (0.42) | POLRMTP2RY2P2RY1P2RY11P2RX1 | |
| SCHEMBL17114363 | 0.81 | SLC28A1 (0.30) | — | |
| SCHEMBL17106834 | 0.81 | SLC28A1 (0.30) | — | |
| SCHEMBL17106741 | 0.80 | POLRMT (0.47) | POLRMTP2RY2P2RY1P2RY11P2RX1 | |
| SCHEMBL17106862 | 0.78 | POLRMT (0.58) | POLRMTP2RY2P2RY1P2RY11P2RX1 | |
| SCHEMBL17111278 | 0.75 | P2RY1 (0.43) | POLRMTP2RY2P2RY1P2RY11P2RX1 | |
| SCHEMBL17106860 | 0.75 | P2RY1 (0.43) | POLRMTP2RY2P2RY1P2RY11P2RX1 | |
| SCHEMBL17133295 | 0.75 | P2RY1 (0.43) | POLRMTP2RY2P2RY1P2RY11P2RX1 | |
| SCHEMBL21078564 | 0.75 | P2RX3 (0.42) | P2RY2P2RY1P2RX1P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122752-A1 | 4'-SUBSTITUTED NUCLEOSIDE-DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-02-01 | — | — | EP | claimed |
| WO-2015148746-A1 | 4'-SUBSTITUTED NUCLEOSIDE-DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-01 | — | — | WO | claimed |
| EP-3122752-A1 | 4'-SUBSTITUTED NUCLEOSIDE-DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-02-01 | — | — | EP | disclosed |
| WO-2015148746-A1 | 4'-SUBSTITUTED NUCLEOSIDE-DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-01 | — | — | WO | disclosed |
| US-8987709-B2 | Arylene containing polymer and organic light-emitting device including the same | SAMSUNG DISPLAY CO., LTD. (KR) | 2015-03-24 | — | — | US | disclosed |