Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17115183 | 0.81 | GAA (0.44) | SMN1; SMN2NPC1RAB9AMAPTHSD17B10 | |
| SCHEMBL17115195 | 0.78 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1RAB9AMAPTHSD17B10 | |
| SCHEMBL25245500 | 0.78 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1RAB9AMAPTHSD17B10 | |
| SCHEMBL17102374 | 0.78 | NPC1 (0.39) | SMN1; SMN2NPC1RAB9AMAPTHSD17B10 | |
| SCHEMBL222470 | 0.78 | SMN1; SMN2 (0.44) | SMN1; SMN2NPC1RAB9AMAPTHSD17B10 | |
| SCHEMBL17102371 | 0.75 | NQO2 (0.49) | SMN1; SMN2NPC1RAB9AMAPTHSD17B10 | |
| SCHEMBL31344809 | 0.74 | SMN1; SMN2 (0.38) | SMN1; SMN2NPC1RAB9AMAPTHSD17B10 | |
| SCHEMBL16518738 | 0.73 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1RAB9AMAPTHSD17B10 | |
| SCHEMBL24401989 | 0.69 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1RAB9AMAPTHSD17B10 | |
| SCHEMBL16437413 | 0.69 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1RAB9AMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015140054-A1 | HETEROARYL SYK INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-09-24 | — | — | WO | disclosed |