Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518738 | 0.72 | SMN1; SMN2 (0.42) | SMN1; SMN2RAB9ANPC1HSD17B10ALDH1A1 | |
| SCHEMBL17115155 | 0.69 | SMN1; SMN2 (0.39) | SMN1; SMN2RAB9ANPC1HSD17B10ALDH1A1 | |
| SCHEMBL17115195 | 0.69 | SMN1; SMN2 (0.39) | SMN1; SMN2RAB9ANPC1HSD17B10ALDH1A1 | |
| SCHEMBL24401834 | 0.68 | SMN1; SMN2 (0.42) | SMN1; SMN2RAB9ANPC1HSD17B10ALDH1A1 | |
| SCHEMBL12046198 | 0.67 | GAA (0.52) | SMN1; SMN2RAB9ANPC1HSD17B10ALDH1A1 | |
| SCHEMBL2171105 | 0.67 | SMN1; SMN2 (0.66) | SMN1; SMN2RAB9ANPC1HSD17B10ALDH1A1 | |
| SCHEMBL15001036 | 0.66 | RAB9A (0.57) | SMN1; SMN2RAB9ANPC1HSD17B10ALDH1A1 | |
| SCHEMBL31344809 | 0.66 | SMN1; SMN2 (0.38) | SMN1; SMN2RAB9ANPC1HSD17B10ALDH1A1 | |
| SCHEMBL16437413 | 0.64 | SMN1; SMN2 (0.43) | SMN1; SMN2RAB9ANPC1HSD17B10ALDH1A1 | |
| SCHEMBL17561709 | 0.64 | RAB9A (0.46) | SMN1; SMN2RAB9ANPC1HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022090481-A1 | SUBSTITUTED 1H-PYRAZOLO[4,3-C]PYRIDINES AND DERIVATIVES AS EGFR INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-05-05 | — | — | WO | disclosed |